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KMID : 0043319920150030256
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Archives of Pharmacal Research
1992 Volume.15 No. 3 p.256 ~ p.262
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The Role of Substituents of ar-Turmerone for its Anticancer Activity
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Oh WG
Baik KU/Jung SH/Ahn BZ
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Abstract
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For the evaluation of the role of substituents of ar-turmerone for its anticancer activity, ar-turmerone (1a) and its analogs like 2-methyl-6-(4’’-methyphenyl)-2-octen-4-one (1b), 2-methyl-6-phenyl-2-hepten-4-one (1c), 2-methyl-6-phenyl-2-octen-4-one (1d), and 2-methyl-6-(trans-4’’-methylcyclohexyl)-2-hepten-4-one (1e) were prepared and their cytotoxic activities against L1210 cell were determined. Omission of methyl group at para-position dose not variate the cytotoxicity of ar-turmerone. Elongation of alkyl group at 6-position decreases ED50 value. Saturation of aromatic ring of ar-turmerone markedly decreases the cytotoxicity. Therefore the smaller size of alkyl group at 6-position and aromatic ring of ar-turmerone should be essential for exhibiting its anticancer activity.
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